Redox proteomics and amyloid βpeptide: insights into Alzheimer disease

DA Butterfield, D Boyd‐Kimball - Journal of neurochemistry, 2019 - Wiley Online Library
… synaptic plasticity and cell structure, neuroinflammation, impaired protein folding … Redox
proteomics analysis of carbonylated proteins in the hippocampus of 3-month-old 3xTg-AD mice

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

ML Young, JL Franklin - Molecular and Cellular Neuroscience, 2019 - Elsevier
… cognitive impairment and dementia coincident with progressive damage to brain neuronal
… include the development of extracellular amyloid plaques in the brain and the formation of …

[HTML][HTML] Mitochondrial molecular abnormalities revealed by proteomic analysis of hippocampal organelles of mice triple transgenic for Alzheimer disease

H Yu, X Lin, D Wang, Z Zhang, Y Guo, X Ren… - Frontiers in molecular …, 2018 - frontiersin.org
… swollen cells to gently lyse the cell membrane. Then, 150 μL … 3xTg-AD mice showed a trend
of mild learning impairment in … , key players in cellular redox function and protection against …

[HTML][HTML] Amyloid-β peptide Aβ3pE-42 induces lipid peroxidation, membrane permeabilization, and calcium influx in neurons

AP Gunn, BX Wong, T Johanssen, JC Griffith… - Journal of Biological …, 2016 - ASBMB
… peroxidation in primary cortical mouse neurons compared with the … Aβ3pE-42 further caused
a loss of plasma membrane integrity … oligomer formation mediated by copper-redox cycling. …

[HTML][HTML] Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's disease …

L Xiao, X Yang, VK Sharma, D Abebe, YP Loh - Molecular Psychiatry, 2023 - nature.com
… , partially improved clearance of amyloid β peptide only in the … in neuronal cell bodies and
plasma membrane where it co-… tau levels in the hippocampus of 3xTg-AD mice 4 months after …

[HTML][HTML] The amyloid-β oligomer hypothesis: beginning of the third decade

EN Cline, MA Bicca, KL Viola… - Journal of Alzheimer's …, 2018 - content.iospress.com
… model brain tissue and, experimentally, to impair learning … of plasma membrane integrity
[173]. Ion channel formation in … loss of neurons in the cerebral cortex and hippocampus, and …

… fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse …

SM Raefsky, R Furman, G Milne, E Pollock… - Neurobiology of …, 2018 - Elsevier
… immunoreactivity in the cerebral cortex and hippocampus of a wild-type mouse (A), an AD
… contribute to cognitive impairment in APP/PS1 double mutant transgenic mice used in the …

[HTML][HTML] Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

A Grimm, EE Biliouris, UE Lang, J Götz… - Cellular and molecular …, 2016 - Springer
… and redox homeostasis was … mouse model of AD (3xTgAD), it has been shown that
orchiectomized males presented with increased Aβ accumulation in the brain, coupled with impaired

… in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox …

F Di Domenico, E Barone, M Perluigi… - Antioxidants & redox …, 2017 - liebertpub.com
… the buildup of amyloid-β peptide and hyperphosphorylated tau… , for the functioning of the
plasma membrane Ca 2+ -ATPase. … Indeed, preventing Aβ accumulation in the 3xTg-AD mouse

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
… Similarly, in the triple transgenic mouse model of AD (3xTg-AD) that … to contribute to impairment
of insulin signaling in AD brain [80]. … Cholesterol in cell membranes, more specifically in …